Previous CTBP Affiliation: Postdoctoral Scholars
Current Institution: India
Research Groups: Onuchic
Department: Physics
Campus Address: 7222 Urey Hall, UCSD, 9500 Gilman Drive, La Jolla, CA 92093-0374
Email:
Campus Phone: (858) 822-6908
Personal Website: http://www.physics.ucsd.edu/~shachi
Research Description:
Interleukin-1B (IL-1B) is an all beta sheet protein with a complex six hairpin fold. This topology seems to make IL-1B slower folding compared to other proteins. One aim of our research is to study the interplay between the energetic landscape and folding kinetics of IL-1B and its topology. Circular permutants of IL-1B have been synthesized in the laboratory. We use Go-model simulations of these circular permutants with enhanced sampling to study the effect of the permutations on the transition state ensemble (TSE).
Most Recent Publications:
| An all-atom structure-based potential for proteins: Bridging minimal models with all-atom empirical forcefields, Whitford, P. C., Noel, J. K., Gosavi, S., Schug, A., Sanbonmatsu, K. Y., Onuchic, J. N., Proteins-Structure Function and Bioinformatics, Vol: 75, Iss: 2, pp. 430-441 (2009) |  |
| Conformational transitions in adenylate kinase. Allosteric communication reduces misligation, Whitford, Paul C., Gosavi, Shachi, Onuchic, Jose N., J. Biol. Chem., Vol: 283, Iss: 4, pp. 2042-8 (2008) |
| The dual-basin landscape in GFP folding, Andrews, B. T., Gosavi, S., Finke, J. M., Onuchic, J. N., Jennings, P. A., Proc. Natl. Acad. Sci. USA, Vol: 105, Iss: 34, pp. 12283-12288 (2008) |
| More Publications |
| Note: The CTBP publication database system contains a record of all papers published by CTBP faculty, post-doctoral scholars and students. The automated retrievel system does not distinguish between CTBP authors and non-CTBP authors with similar initials/names, hence on rare occassions it incorrectly will include a citation for paper that was not the work of the CTBP person listed (but a CTBP collaborator with similar initials/name). |