Water is ubiquitous at protein-DNA interfaces (e.g., the Zif268-GCN4-DNA complex depicted here) and may contribute to high specificity
From Water Mediation in Protein Folding and Molecular Recognition, Annu. Rev. Biophys. Biomol. Struct., 35:389-415 (2006)
Onuchic Group
CTBP encompasses a broad array of research and training activities at the forefront of the biology-physics interface. Research within CTBP focuses on the following broadly defined areas: Cellular Tectonics Gene Regulatory Networks, and Computational Approaches to Intracellular and Intercelllular Communication
Our mission is to conduct and foster research aimed at providing a quantitative framework for unraveling the workings of complex biological processes.